Objective: To study. using the technique of cerebral microdialysis. markers of cerebral metabolism within the penumbra surrounding a spontaneous Intracerebral Haemorrhage (ICH).
Design: Following consent/assent patients underwent insertion of a catheter into the perihaematoma area of low density, 'the penumbra' with a second reference catheter in 'normal' brain. Dialysate samples were collected hourly for the duration of monitoring.
Conclusion: This present study of cerebral metabolism in patients following ICH demonstrates evidence of ischaemia within the penumbra of an ICH which worsens over time. Clot evacuation improved markers of cerebral metabolism. These data suggest a much longer therapeutic window following ICH than earlier thought and perhaps a role for surgical intervention in the prevention/minimisation of secondary ischaemic neuronal damage.
Fernandes HM, Chambers I, Deogaonkar A, Woolridge T, Mendelow AD. Evaluation of changes in Cerebral metabolism after Intracerebral Haemorrhage. British Neurosurgery Research Group meeting, Sheffield, 29-30 March 2001.
Dr. Iain R. Chambers, Cleveland Unit, Middlesbrough. Tel: +44 (0)1642-854-778.
Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.
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