Introduction: Secondary pathophysiological CPP insult is related to outcome after head injury, and improved management would be expected to reduce secondry brain insult. Paediatric Head Injury management guidelines have been published in recent years, by SIGN (2000), RCPCH (2001), NICE (June 2003), and jointly by Critical/Intensive Care Societies (C/ICS July 2003).
We investigated whether outcome of children's Head Injury (and total burden of secondary CPP insult) has changed i) annually; ii) before and after the introduction of any HI guidelines, and iii) following other service changes.
Methods: 76 children (aged 1 -<15 years with severe HI) were admitted to the Edinburgh Regional Head Injury Service between 1989 and 2006, and dichotomised at various time points and compared in terms of: demographic factors, Intracranial Pressure (ICP), Cerebral Perfusion Pressure (CPP) insults (eg. age-banded Pressure-Time Index (PTI)), and Glasgow Outcome Scale (GOS) score (assessed at 6 months post injury).
Results: When dichotomised around the SIGN guidelines, there were no statistically significant differences between the 2 group's demography or in primary brain injury, but the outcomes were different (p=0.03), with 6, 2, 5 & 23 having GOS1 (died), GOS3 (severely disabled), GOS 4 (moderately disabled) and GOS5 (good recovery) before, compared to 4, 4, 16& 14 respectively post-2000. GOS4 was significantly different (Chi Sq= 4.314, p<0.05). There was a (non-significant) trend for the later years to have longer insult durations of ICP, hypertension, CPP, hypoxia, pyrexia, tachycardia and bradycardia, greater PTI for both CPP and ICP, and more CPP insults (p=0.003). There was, however, significantly less CPP insult (p=0.009) after the introduction of the more management-oriented C/ICS guidelines
Conclusions: The most recent paediatric HI guidelines appear to have reduced the burden of secondary insult, but more time is required to determine if this will be reflected in improved outcomes.
Jones PA, Chambers IR, Minns RA, Lo TYM, Myles LM, Steers AWJ. Are Head Injury Guidelines changing the outcome of head injured children? A regional investigation. International Symposium on Intracranial Pressure and Brain Monitoring, Mechanisms and Treatment. 23rd July 2007, San Francisco.
Dr. Iain R. Chambers, Cleveland Unit, Middlesbrough. Tel: +44 (0)1642-854-778.
Regional Medical Physics Department, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK.
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