Approximately 200 peer-reviewed publications and conference presentations are made each year by the Department's staff. Click on the Publications link to view publications and presentations made by our staff since 1998.
O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using (123)I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations. Neuroimage, 2008. [Read Abstract]
Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, Williams ED, McKeith IG, O'Brien JT. The effects of donepezil on nicotinic receptor status in dementia: a 123I-5IA-85380 SPECT study. J Neurol Neurosurg Psychiatry. 2007 Dec 12 [Epub ahead of print]. [Read Abstract]
Firbank MJ, Barber R, Burton EJ, O'Brien JT. Validation of a fully automated hippocampal segmentation method on patients with dementia. Hum Brain Mapp. 2007 Nov 2. [Read Abstract]
O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. Alpha4beta2 nicotinic receptor status in Alzheimer's disease using 1231-51A-85380 single-photon-emission computed tomography. J Neurol Neurosurg Psychiatry. 2007. 78; 356-62. [Read Abstract]
Pakrasi S, Colloby SJ, Firbank MJ, Perry EK, Wyper DJ, Owens J, McKeith IG, Williams ED, O'Brien JT. Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 1231-QNB SPECT. J Neurol. 2007. 254;907-13. [Read Abstract]
Taylor JP, Colloby SJ, McKeith IG, Burn DJ, Williams D, Patterson J, O'Brien JT. Cholinesterase inhibitor use does not significantly influence the ability of 1231-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies. J. Neurol Neurosurg Psychiatry. 2007. 78;1069-71. [Read Abstract]
Burton EJ, McKeith IG, Burn DJ, Firbank MJ, O'Brien JT. Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging. Am J Geriatr Psychiatry. 2006 Oct;14(10):842-9. [Read Abstract]
Colloby SJ, Pakrasi S, Firbank MJ, Perry EK, Piggott MA, Owens J, Wyper DJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) (123)I-QNB in dementia with Lewy bodies and Parkinson's disease dementia. Neuroimage. 2006 Sep 4 (eprint only at moment) http://dx.doi.org/10.1016/j.neuroimage.2006.07.026. [Read Abstract]
Coulthard E, Firbank M, English P, Welch J, Birchall D, O'Brien J, Griffiths TD. Proton magnetic resonance spectroscopy in frontotemporal dementia. J Neurol. 2006 Jul;253(7):861-8. http://dx.doi.org/10.1007/s00415-006-0045-y. [Read Abstract]
Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison R, O'Brien JT. Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease. Neuroimage. 2007 May 15;36(1):1-7. Epub 2007 Feb 28. [Read Abstract]
Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison RM, O'Brien JT. Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease. Psychiatry Res. 2007 Jul 15;155(2):135-45. Epub 2007 Apr 3. [Read Abstract]
Firbank MJ, Burton EJ, Barber R, Stephens S, Kenny RA, Ballard C, Kalaria RN, O'Brien JT. Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors. Neurobiol Aging. 2006 Aug 23 (eprint only at moment). http://dx.doi.org/10.1016/j.neurobiolaging.2006.07.009. [Read Abstract]
Firbank MJ, Wiseman RM, Burton EJ, Saxby BK, O'Brien JT, Ford GA. Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure : Brain atrophy, WMH change and blood pressure. J Neurol. 2007 Jun;254(6):713-21. Epub 2007 Apr 20. [Read Abstract]
Kane AD, Iqbal M, Richardson MA, Bradey N, Scoones D, Kane PJ. The predictive value of Thallium SPECT scanning in the management of patients with supratentorial primary brain tumours: an audit of scan results and histology. 7th Congress of the European Association for Neuro-oncology, Vienna, Sept. 2006. [Read Abstract]
Krishnan MS, O'Brien JT, Firbank MJ, Pantoni L, Carlucci G, Erkinjuntti T, Wallin A, Wahlund LO, Scheltens P, van Straaten EC, Inzitari D. Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study. Int J Geriatr Psychiatry. 2006 (eprint only at moment) http://dx.doi.org/10.1002/gps.1596. [Read Abstract]
O'Brien JT, Firbank MJ, Krishnan MS, van Straaten EC, van der Flier WM, Petrovic K, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund LO, Inzitari D; LADIS Group. White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study. Am J Geriatr Psychiatry. 2006 Oct;14(10):834-41. [Read Abstract]
Colloby SJ, Williams ED, Burn DJ, Lloyd JJ, McKeith IG, O'Brien JT. Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT. Eur J Nucl Med Mol Imaging 2005; 32:1176-1185. [Read Abstract]
Firbank MJ, O'Brien JT, Pakrasi S, Pantoni L, Simoni M, Erkinjuntti T, et al. White matter hyperintensities and depression - preliminary results from the LADIS study. International Journal of Geriatric Psychiatry 2005;20:674-679. [Read Abstract]
Firbank MJ, Burn DJ, McKeith IG, O'Brien JT. Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies. International Journal of Geriatric Psychiatry 2005;20:776-782. [Read Abstract]
Firbank MJ, Molloy S, McKeith IG, Burn DJ, O'Brien JT. Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year. Journal of Neurology, Neurosurgery & Psychiatry 2005;76:1448-1451. [Read Abstract]
O'Brien JT, Firbank MJ, Mosimann UP, Burn DJ, McKeith IG. Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy Bodies. Psychiatry Research: Neuroimaging 2005;139(2):79-88. [Read Abstract]
Lamb PJ, Griffin SM, Burt AD, Lloyd J, Karat D, Hayes N. Sentinel node biopsy to evaluate the metastatic dissemination of oesophageal adenocarcinoma. Br J Surg. 2005 Jan;92(1):60-7. [Read Abstract]
Burton EJ, Kenny RA, O'Brien J, Stephens S, Bradbury M, Rowan E, Kalaria R, Firbank M, Wesnes K, Ballard C. White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients. Stroke. 2004 Jun;35(6):1270-5. [Read Abstract]
Colloby SJ, O'Brien JT, Fenwick JD, Firbank MJ, Burn DJ, McKeith IG, Williams ED. The application of statistical parametric mapping to (123)I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease. Neuroimage. 2004 Nov;23(3):956-966. [Read Abstract]
Firbank MJ, Lloyd AJ, Ferrier IN, O'Brien JT. A volumetric study of MR signal hyperintensities in old age depression. American Journal of Geriatric Psychiatry 12(6) 606-612. [Read Abstract]
O'Brien JT, Colloby S, Fenwick J, Williams ED, Firbank M, Burn D, Aarsland D, McKeith IG. Dopamine Transporter Loss Visualized With FP-CIT SPECT in the Differential Diagnosis of Dementia With Lewy Bodies. Archives of Neurology 2004; 61:919-925. [Read Abstract]
Paling SM, Williams ED, Barber R, Burton EJ, Crum WR, Fox NC, O'Brien JT. The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia. Medical Image Analysis 2004; 8: 69-79. [Read Abstract]
Firbank MJ, Minett T, O'Brien JT. Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects. Neurology 2003; 61: 950-954. [Read Abstract]
Firbank MJ, Colloby SJ, Burn DJ, McKeith IG, O'Brien JT. Regional cerebral blood flow in Parkinson's disease with and without dementia. Neuroimage 2003; 20: 1309-1319. [Read Abstract]
Karas GB, Burton EJ, Rombouts SARB, van Schijndel RA, O'Brien JT, Scheltens PH, McKeith IG, Williams D, Ballard C, Barkhof F. A comprehensive study of grey matter loss in patients with Alzheimers disease using optimized voxel-based morphometry. Neuroimage 18 (2003) 895-907. [Read Abstract]
Piggott MA, Owens J, O'Brien J, Colloby S, Fenwick J, Wyper D, Jaros E, Johnson M, Perry RH, Perry EK. Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinsons disease and Alzheimers disease. Journal of Chemical Neuroanatomy 2003; 25: 161-173. [Read Abstract]
Sims AJ, Bennett MK, Murray A. Image analysis can be used to detect spatial changes in the histopathology of pancreatic tumours. Phys. Med. Biol. 48 (2003) N183-NI91. [Read Abstract]
Burton EJ, Karas G, Paling SM, Barber R, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT. Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. Neuroimage 2002; 17: 618-630. [Read Abstract]
Colloby SJ, Fenwick JD, Williams ED, Paling SM, Lobotesis K, Ballard C, McKeith I, O'Brien JT. A comparison of Tc99m-HMPAO SPET changes in dementia with Lewy bodies and Alzheimers disease using statistical parametric mapping. Eur J Nuc Med 2002; 29: 615-622. [Read Abstract]
Esgiar AN, Naguib RNG, Sharif BS, Bennett MK, Murray A. Fractal analysis in the detection of colonic cancer images. IEEE Trans Info Technol Biomed 2002; 6: 54-8. [Read Abstract]
Sims AJ, Bennett MK, Murray A. Comparison of semi-automated image analysis and manual methods for tissue quantification in pancreatic carcinoma. Phys Med Biol 2002; 47: 1255-1266. [Read Abstract]
Varma AR, Adams W, Lloyd JJ, Carson KJ, Snowden JS, Testa HJ, Jackson A, Neary D. Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimers disease, frontotemporal dementia and vascular dementia. Acta Neurol Scand 2002: 105: 261-269. [Read Abstract]
Varma AR, Laitt R, Lloyd JJ, Carson KJ, Snowden JS, Neary D, Jackson A. Diagnostic value of high signal abnormalities on T2 weighted MRI in the differentiation of Alzheimer's, frontotemporal and vascular dementias. Acta Neurol Scand 2002: 105: 355-364. [Read Abstract]
Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, McKeith IG, O'Brien JT. Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD. Neurology 2001;56:643-649. [Read Abstract]
Martin SD, Martin E, Rai SS, Richardson MA, Royall RA. Brain blood flow changes in depressed patients treated with interpersonal psychotherapy or venlafaxine hydrochloride: preliminary findings. Arch Gen Psychiatry 2001; 58: 641-653. [Read Abstract]
O'Brien JT, Paling S, Barber R, Williams ED, Ballard C, McKeith IG, et al. Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia. Neurology 2001; 56:1386-8. [Read Abstract]
Barber PA, Varma AR, Lloyd JJ, Haworth B, Snowden JS, Neary D. The electroencephalogram in dementia with Lewy bodies. Acta Neurologica Scandinavica 2000; No 101, 1: 53-6. [Read Abstract]
Davies M, Owst D. An X-ray test object in Meccano. Constructor Quarterly 2000; 50: 42-44. [Read Abstract]
Firbank MJ, Harrison RM,Williams ED, Coulthard A. 2000 Quality assurance for MRI: practical experience. Brit. J Radiol. 73:376-383. [Read Abstract]
Firbank MJ, Coulthard A. Evaluation of a technique for estimation of extraocular muscle volume using 2D MRI Brit. J Radiol. 73 (2000), 1282-1289. [Read Abstract]
Paling S, Barber R, Williams ED, Gholkar AL, Crum WR, Fox N, et al. Measurement of progressive brain atrophy in dementia with Lewy bodies using serial MRI: a comparison with Alzheimers disease, vascular dementia and normal ageing. International Psychogeriatric Association Conference, Newcastle, April 2000. [Read Abstract]
Doherty JG, Ruler A, Bartholomew PH, Beaumont, DM. The Presentation, Treatment, and Outcome of Renal Cell Carcinoma in Old Age, Age and Ageing 28:359-362. [Read Abstract]
Esgiar AN, Sharif BS, Naguib RNG, Bennett MK, Murray A. Texture descriptions and classification for pathological analysis of cancerous colonic mucosa. In: Image Processing and its Applications. London: Institution of Electrical Engineers, 335-8. [Read Abstract]
Firbank MJ, Coulthard A, Harrison RM,Williams ED. Partial volume effects in MRI studies of multiple sclerosis. Magnetic Resonance Imaging 17(4) 593-601. [Read Abstract]
Firbank MJ, Coulthard A, Harrison RM,Williams ED. A comparison of two methods for measuring the signal to noise ratio on MR images. Phys. Med. Biol. 44(12) N261-N264. [Read Abstract]
Varma AR, Snowdon JS, Lloyd JJ, Talbot PR, Mann DMA, Neary D. Evaluation of the NINCDA-ADRDA criteria in the differentiation of Alzheimers disease and fronto temporal dementia. Journal of Neurology, Neurosurgery and Psychiatry, 66, 184-188. [Read Abstract]
Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, NE7 7DN, UK.
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Regional Medical Physics Department, a Clinical Directorate of the Newcastle upon Tyne Hospitals NHS Foundation Trust.
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