Disturbances in the cerebral cholinergic nervous system and subsequent reduction of acetylcholine (ACh) are neurochemical features of AD and DLB, and treatments with acetylcholinesterase inhibitors (AChEIs) offer symptomatic improvement in cognitive and non-cognitive symptoms. One important subclass of acetylcholine receptors are nicotinic acetylcholine receptors (nAChR), and have been shown to be implicated in memory and cognitive processes.
Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, Williams ED, McKeith IG, O'Brien JT. The effects of donepezil on nicotinic receptor status in dementia: a 123I-5IA-85380 SPECT study. J Neurol Neurosurg Psychiatry. 2007 Dec 12 [Epub ahead of print].
Professor E. David Williams, Sunderland Unit, Sunderland. Tel: +44 (0)191-569-9035.
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