The aim of this work was to validate the implementation of a gamma camera method (Gates' method) for estimating glomerular filtration rate (GFR). Forty patients had a dynamic renogram study following intravenous administration of 200 MBq of 99mTc-DTPA. The GFR was estimated from the renogram using a commercial software implementation of Gates' method. The GFR was also estimated by analysing 10 ml venous blood samples obtained at 2, 3 and 4 h post-injection using a single exponential slope - intercept method. The paired GFR results thus obtained were compared, using the multiple plasma sample method as the reference. The comparison demonstrated that, while there is a good correlation between the paired results (P<0.05), there is significant difference between individual results. Reasons for this may include inaccuracies in renal depth estimation. In conclusion, GFR estimates using the gamma camera method with the software implementation described may give unreliable results.
Cowley M, Belton I, Krukowski P, Mattison C. Validation of a gamma camera method for estimating GFR. Nuc Med Commun 2003; 24: 479.
Mr Martin J Cowley, Cumbria Unit, Carlisle. Tel: +44 (0)1228-523-444.
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